Looking at the reception desk and the pigeon-hole cabinet behind the desk clerks, it seems rather clear that it is the lobby of a hotel. (You may not be able to see it, but a sign above the cabinet is addressed to "guests.") But which hotel is it? We have no information with this photograph as to where it was taken. Any ideas?
We do know that one of the ladies in the photo is Miss Mary Spier -- it might be possible, with a bit of research, to learn more about Miss Spier -- using the Ancestry genealogy database, for example. We can make a reasonable "guesstimate" of the time period of this photo by looking at things such as the "candlestick" telephone on the counter; these phones were popular mainly in the 1910s and 1920s. A map expert might be able to date the photo by the map on the wall. (Not me.)
Remember: just because you don't know all the details about a photograph, it doesn't mean it's worthless. Every image offers a description of life; it's just up to you to figure out what they are saying.
So where was this hotel? Your ideas are welcome.