The 1855 Sandusky City Directory lists several businesses on Tiffin Avenue, including a barber, cooper, blacksmith, and a grocer. David Bruckner and Florian Ulmer had a blacksmith shop on Tiffin Avenue near Monroe Street in the 1880s.
Mrs. Conrad Frank’s bakery was located first at Tiffin Avenue, but later moved to Columbus Avenue.
The Kuebeler brewing plant was built on Tiffin Avenue near Broadway Street in 1893, after the previous brewery was destroyed in a fire. In 1896 the Kuebeler and Stang breweries merged to form the Kuebeler-Stang Brewing Company. Two years later the Kuebeler- Stang Brewery became part of the Cleveland and Sandusky Brewing Company. Most of the breweries in Sandusky closed during Prohibition. One of the Kuebeler-Stang plants survived by making soft drinks, but it too closed in 1935, and all remaining beer production moved to Cleveland.
The Industrial Nut Corporation, which began as the Brightman Nut and Manufacturing Company, has been located on Tiffin Avenue for one hundred years.
George J. Bing built carriages at his garage on Tiffin Avenue in the early twentieth century, before his untimely death in 1914.