From the early 1860s until his death in 1898, Harry Colton was the proprietor of the Colton House, a hotel located in Sandusky at the southeast corner of Lawrence and Water Streets. It was situated just across from the docks of the Big Four railway and its predecessors. A portion of the 1886 Sanborn Map shows the location of the business. There was a saloon and billiards hall on the portion of the hotel that faced Water Street, and the hotel’s rooms were located along the side of the hotel which faced Lawrence Street.
Harry Colton died on May 8, 1898. After his death, the Colton House was operated by his wife, and later by his sons. By the early twentieth century, other owners had taken over the business. In 1905 the hotel became known as the Hotel Lawrence. The building was razed in the fall of 1932.
Harry and Susanna Colton and several of the extended Colton family are buried in Block 60 of Sandusky’s Oakland Cemetery.