Here is a crop of a single frame, which might make it a little easier to see things. (The original is not of great quality).
Update: Told you it was an easy one. Our first commenter had the correct answer. It shows the corner of Columbus Avenue and (what is now) East Adams Street, viewed from the courthouse. Some of the buildings in the scene are still standing today, nearly 140 years later, although some have been modified. In the left forground is the Emmanuel Church. It was expanded in the 1950s, and had been remodeled well before then as well. In the background, you can see homes on Wayne Street that are still recognizable, including the Follett House, the Moss house, and Hubbard houses. In the distance is the German Reformed Church, now the site of First Faith Community Church.